Matrine

Matrine

Ku shen (the root) or kushenin (a pterocarpan, an isoflavonoid compound) is a typical traditional Chinese medicine that is found in this plant. It is commonly used for the treatment of viral hepatitis, enteritis, viral myocarditis, gastrointestinal hemorrhage[non-primary source needed] and skin diseases (such as colpitis, psoriasis and eczema);

Its roots contain quinolizidine alkaloids, includying matrine and its oxide, matrine oxide that interfere TNF-alpha and IL-6, suggesting that oxymatrine may inhibit the expression of the above pro- inflammatory cytokines.

Matrine also inhibited expression of Substance P and NK-1R in a human model of skin inflammation, as well as acting as an agonist at mu and kappa opioid receptors;

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